Fast-dissolving drug technologies are rapidly gaining interest in the pharmaceutical industry. These delivery systems either dissolve or disintegrate in the mouth rapidly, without requiring any water to aid in swallowing. Such technologies offer a convenient way of dosing medications, not only to special population groups with swallowing difficulties, but also to the general population. They also impart unique product differentiation, thus enabling use as line extensions for existing commercial products. This review discusses the various technologies used to achieve quick dissolution/dispersion in the oral cavity. They are categorized based on either processing or formulation variables. Processing techniques, such as Zydis, Quick-Dis, Soluleaves, Wafertab are discussed in this article. The oral mucosa has rich blood supply and it is relatively permeable. The permeability of the buccal mucosa is 4- 1000 time greater then that of skin. the administration of drugs by the oral route has several advantage over per oral administration such as QWICK ACTION, avoid of first pass metabolism , drug is not subject to acidic environment of the stomach and also the improved patient compliance particularly with pediatric & geriatric patient. It is the objective of this article to review the oral fast dissolving drug delivery such as fast dissolving/disintegrating film & tablet, fast dissolving capsule and medicated chew gum etc.
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